The L368 pill is a commonly used over-the-counter medication trusted for managing mild to moderate pain and inflammation. With its imprint “L368” and oblong white appearance, this pill contains naproxen sodium 220 mg, an effective NSAID (Nonsteroidal Anti-Inflammatory Drug). It’s widely used for conditions ranging from muscle aches to menstrual cramps, and it plays a vital role in acute pain relief and long-term inflammation management.
Whether you’re experiencing back pain or a low-grade fever, knowing how to properly use L368 — and understanding its limitations — can help you stay safe and symptom-free.
🔑 Key Takeaways
- L368 is a non-prescription pill containing naproxen sodium 220 mg, a powerful NSAID used to relieve pain, reduce inflammation, and lower fever.
- Offers long-lasting relief for 8–12 hours, making it effective for conditions like headaches, menstrual cramps, arthritis, muscle pain, and backaches.
- It’s a generic version of Aleve, manufactured by Perrigo, and is FDA-approved for over-the-counter use.
- It should be taken with food or milk to minimize stomach irritation. Avoid use if you have ulcers, kidney issues, or cardiovascular disease.
- Clinical studies back its safety and efficacy, especially in comparison to other NSAIDs like ibuprofen or diclofenac.
- Not suitable for children under 12, pregnant women in the third trimester, or individuals on conflicting medications.
- Safe when used as directed—do not exceed 3 tablets in 24 hours and avoid mixing with alcohol or other NSAIDs.
What Exactly Is L368?
The L368 tablet is produced by Perrigo, a well-known generic pharmaceutical manufacturer. It’s the generic form of Aleve, a naproxen-based drug used for its anti-inflammatory and analgesic properties. It is categorized as an NSAID, meaning it works by reducing the hormones in your body that cause pain and inflammation.
This medication is accessible without a prescription, which makes it convenient, but not risk-free. While L368 offers strong relief, understanding the correct usage is crucial to avoid side effects and drug interactions.
Medical Uses of L368 (Naproxen 220 mg)
Naproxen, the active ingredient in L368, is a versatile and trusted remedy for several conditions. It is generally recommended for short-term relief, but in some cases, it may be used under medical supervision for ongoing issues.
Common Conditions Treated With L368
- Headaches and Migraines
- Provides fast relief from tension-type headaches and helps reduce the pain from mild migraines.
- Muscle Aches and Strains
- Ideal for sore muscles after a workout or muscle strain caused by physical activity.
- Menstrual Pain (Dysmenorrhea)
- L368 is especially effective in easing period cramps due to its anti-inflammatory action.
- Joint Pain and Arthritis
- Used for osteoarthritis and rheumatoid arthritis symptoms like swelling, stiffness, and joint pain.
- Dental Pain
- A popular remedy for post-procedural toothaches and gum inflammation.
- Fever and Cold-Related Pain
- Helps reduce body temperature and provides comfort during flu or viral fevers.
- Back Pain and Sciatica
- Offers relief from inflammation in the lower back or spine.
How L368 Works: Mechanism of Action
L368 reduces pain and inflammation by blocking cyclooxygenase (COX) enzymes, primarily COX-1 and COX-2. These enzymes are involved in producing prostaglandins — chemicals that trigger inflammation, pain, and fever responses in the body.
By inhibiting these enzymes, naproxen reduces the production of prostaglandins, lowering pain perception and decreasing inflammation at the site of injury or irritation.
Dosage Guidelines for Safe Use
For Adults and Teens (12+ years)
- Take 1 tablet every 8 to 12 hours as needed.
- For the first dose, you may take 2 tablets within the first hour.
- Do not exceed 3 tablets in 24 hours.
For Seniors
- Older adults should use the lowest effective dose due to an increased risk of gastrointestinal bleeding and kidney issues.
Special Considerations
- Always take with food or milk to avoid gastric irritation.
- Avoid taking it on an empty stomach.
- Never combine L368 with other NSAIDs like ibuprofen or aspirin unless advised by a doctor.
Who Should NOT Take L368?
While the L368 pill is effective for most people, it is not safe for everyone. Specific health conditions and existing medications may create severe interactions or side effects.
Avoid L368 If You:
- Have a history of stomach ulcers or GI bleeding.
- Are in the third trimester of pregnancy
- Are you taking blood thinners or anticoagulants
- Have chronic kidney disease
- Suffer from uncontrolled hypertension or heart disease.
- Have a sensitivity to NSAIDs
Always consult a healthcare provider if you are unsure about L368’s compatibility with your current health condition or medication regimen.
L368 Side Effects: What You Should Know
Most users tolerate the L368 pill well, but as with any medication, side effects can occur.
Mild Side Effects
- Nausea
- Drowsiness
- Indigestion
- Heartburn
- Mild headache
Severe or Rare Side Effects (Seek immediate help)
- Blood in stools or vomit
- Severe stomach pain
- Chest tightness or shortness of breath
- Swelling of the face, tongue, or throat
- Skin rash or blistering
If any severe symptoms occur, stop using the medication immediately and seek emergency medical attention.
Drug Interactions to Watch Out For
Drug interactions may reduce L368’s effectiveness or increase the risk of side effects. Inform your healthcare provider if you’re using:
- Aspirin or other NSAIDs
- Steroids (like prednisone)
- Antidepressants
- Diuretics or “water pills”
- ACE inhibitors (for high blood pressure)
- Lithium
- Methotrexate
When in doubt, check with your doctor or pharmacist before combining L368 with other medications.
How Naproxen Compares to Other NSAIDs
Naproxen has been the subject of numerous clinical studies that compare it with other popular NSAIDs like ibuprofen, diclofenac, and celecoxib. According to a landmark study published in the New England Journal of Medicine, naproxen provides similar levels of pain relief as other NSAIDs but with a lower cardiovascular risk profile.
This finding is important for people who require regular pain management, such as those suffering from arthritis, joint pain, or chronic inflammation. The study supports naproxen as a safer option, especially for individuals with underlying heart conditions.
Furthermore, a 2016 meta-analysis in the British Medical Journal (BMJ) concluded:
“Among traditional NSAIDs, naproxen is associated with the least risk of major vascular events.”
These findings help explain why healthcare professionals often recommend L368 for long-term or recurring pain over other NSAIDs that may pose greater risks.
Safe Storage and Handling
- Store at room temperature between 20°C to 25°C (68°F to 77°F).
- Keep the tablets in a dry, sealed container.
- Always check the expiration date before use.
- Dispose of expired medication responsibly—do not flush it down the toilet.
Final Thoughts: Should You Choose the L368 Pill?
The L368 pill is a powerful, affordable, and easy-to-access option for dealing with multiple types of body pain and inflammation. Its long-lasting effects, combined with the safety of an OTC option, make it a top choice for people who need relief on the go.
However, like all NSAIDs, it should be taken with caution and awareness of potential risks. If your pain persists longer than 10 days or worsens, consult your physician for a more thorough diagnosis.
Whether you’re dealing with a minor muscle strain or a recurring condition like arthritis, the L368 pill (naproxen sodium) can be a smart solution when used wisely.
📌 Frequently Asked Questions (FAQs)
❓ What is the L368 pill?
The L368 pill is a small, round, green tablet imprinted with “L368.” It has been identified as Meclizine Hydrochloride 25 mg, an over-the-counter medication commonly used to treat nausea, vomiting, and dizziness caused by motion sickness or vertigo.
❓ What is Meclizine used for?
Meclizine is an antihistamine primarily used to:
- Prevent and treat motion sickness
- Manage symptoms of vertigo
- Reduce dizziness, nausea, and vomiting associated with inner ear conditions like Ménière’s disease
❓ Is the L368 pill available over the counter?
Yes, the L368 pill (Meclizine 25 mg) is available without a prescription in the United States. However, it’s important to follow dosage instructions on the label or as directed by a healthcare provider.
❓ How should I take the L368 pill?
For motion sickness, take the pill 1 hour before travel. The usual adult dose is:
- 25–50 mg once daily, or as directed
For vertigo, consult a physician for a tailored dose.
❓ Does the L368 pill make you sleepy?
Yes, drowsiness is a common side effect of Meclizine. You should avoid driving or operating heavy machinery until you know how the medication affects you.
❓ Can I take the L368 pill while pregnant?
Meclizine is classified as Pregnancy Category B, which means it’s generally considered safe during pregnancy, but you should always consult your doctor before taking any medication while pregnant
❓ Can children take the L368 pill?
The L368 pill is usually not recommended for children under 12 years old unless advised by a healthcare provider. Always read the label or consult a pediatrician
❓ What are the side effects of the L368 pill?
Common side effects may include:
- Drowsiness
- Dry mouth
- Headache
- Blurred vision
Seek medical attention if you experience severe side effects like difficulty breathing or allergic reactions.
❓ Can I take Meclizine with alcohol?
No. Combining Meclizine (L368 pill) with alcohol can increase drowsiness and dizziness, making it unsafe. It’s best to avoid alcohol while using this medication.
❓ Is Naproxen same as Dramamine?
Not exactly. While both are used for motion sickness, the L368 pill contains Meclizine, while original Dramamine contains Dimenhydrinate. However, Dramamine Less Drowsy formula also contains Meclizine and is similar to the L368 pill.
❓ How long does the effect of Naproxen last?
The effects of Meclizine (L368 pill) typically last 12 to 24 hours, making it effective for all-day motion sickness or vertigo relief.
